Alcohol septal ablation for obstructive hypertrophic cardiomyopathy.
نویسنده
چکیده
Treatment of obstructive hypertrophic cardiomyopathy remains challenging. Medical therapy, surgical therapy, and pacemaker therapy have been shown to be beneficial in some patients over the years. Alcohol septal ablation is a catheter-based intervention that causes a controlled infarct in the septum leading to a decrease in the left ventricular outflow tract obstruction. Along with the impressive reductions in left ventricular outflow tract gradient, there is subjective and objective improvement in symptoms. Development of complete heart block requiring a permanent pacemaker after alcohol septal ablation remains a frequent complication, but has decreased in some recent studies. Alcohol septal ablation has been shown to improve diastolic function, decrease mitral regurgitation, decrease left ventricular hypertrophy and mass, as well as cause changes at the cellular and molecular level that improve myocardial function. Comparison of alcohol septal ablation to surgical myectomy has shown favorable results. Long-term follow-up of alcohol septal ablation has shown sustained results out to several years.
منابع مشابه
Letter by ElBardissi regarding article, "Outcome of alcohol septal ablation for obstructive hypertrophic cardiomyopathy".
BACKGROUND The clinical efficacy of alcohol septal ablation for drug-refractory hypertrophic cardiomyopathy remains unclear. This study examines the outcome of alcohol septal ablation performed at a tertiary hypertrophic cardiomyopathy referral center. METHODS AND RESULTS Among 601 patients with severely symptomatic obstructive hypertrophic cardiomyopathy referred for alcohol septal ablation ...
متن کاملManagement of Hypertrophic Obstructive Cardiomyopathy with a Focus on Alcohol Septal Ablation
متن کامل
How Symptomatic Should a Hypertrophic Obstructive Cardiomyopathy Patient Be to Consider Alcohol Septal Ablation?
Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry Josef Veselka, Lothar Faber, Max Liebregts, Robert Cooper, Jaroslav Januska, Jan Krejci, Thomas Bartel, Maciej Dabrowski, Peter Riis Hansen, Vibeke Marie Almaas, Hubert Seggewiss, Dieter Horstkotte, Radka A...
متن کاملTwenty Years of Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy
Hypertrophic obstructive cardiomyopathy is the most common genetic cardiac disease and is generally characterised by asymmetric septal hypertrophy and intraventricular obstruction. Patients with severe obstruction and significant symptoms that persist despite optimal medical treatment are candidates for an invasive septal reduction therapy. Twenty years after its introduction, percutaneous tran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Heart
دوره 92 9 شماره
صفحات -
تاریخ انتشار 2003